SpamNet is a spam filtering system which has won plenty of friends for the clever, distributed way it attacks spam (read a review of SpamNet by David Moss). It costs $3.99 a month (with a one month free trial) and requires a Windows PC running Microsoft's Outlook email program.
The Mozilla web browser has spam filtering built into its email function. Mozilla is available for most computers including Windows, Mac OSX and Linux, and it's a free download.
Apple users can also make use of Mail, the email program that comes as part of the company's OSX operating system. It has a spam filtering system that gets progressively better the more you use it. Mac users might also want to look at Spamfire, which also works for OS9 users.
Other popular products (all for PC users) include Mailwasher, SpamEater Pro and SpamPal.
There's a long list of anti-spam tools from spam.abuse.net if you want to try other solutions